A systematic review and meta-analysis of hypocalciuria in pre-eclampsia

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#calcium #chronic-disease #female #humans #hypertension

A systematic review and meta-analysis of hypocalciuria in pre-eclampsia

McMaster et al., 2017 | Int J Gynaecol Obstet | Meta Analysis

Citation

McMaster Kristen M, Kaunitz Andrew M, ... Sanchez-Ramos Luis. A systematic review and meta-analysis of hypocalciuria in pre-eclampsia. Int J Gynaecol Obstet. 2017-Jul;138(1):3-11. doi:10.1002/ijgo.12165

Abstract

BACKGROUND: Small observational studies have demonstrated that pre-eclampsia is associated with hypocalciuria. OBJECTIVES: To compare urinary calcium excretion in pre-eclampsia, gestational hypertension, and chronic hypertension with that in normotensive pregnancies. SEARCH STRATEGY: Online databases were searched through February 2016 using medical subject headings "calcium homeostasis," "calcium excretion," "hypocalciuria," and "pre-eclampsia." SELECTION CRITERIA: Observational studies were included that evaluated calcium excretion with 24-hour urine collection in patients with pre-eclampsia compared with normotensive pregnant women. DATA COLLECTION AND ANALYSIS: Data were extracted from identified studies. The primary outcome was 24-hour urinary calcium excretion. Weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated. MAIN RESULTS: Twenty-one studies were included. Urinary calcium excretion was lower among women with pre-eclampsia than among those with normotensive pregnancies (WMD -158.43, 95% CI -187.95 to -128.92) or chronic hypertension (WMD -92.92, 95% CI -100.55 to -85.29). Excretion was also reduced in severe versus mild pre-eclampsia (WMD -35.00, 95% CI -58.94 to -11.07) and gestational hypertension versus normotensive pregnancies (WMD -50.95, 95% CI -57.74 to -44.17). Calcium excretion was not significantly lower in chronic hypertension versus normotensive pregnancies (WMD -64.45, 95% CI -135.98 to 7.08). CONCLUSIONS: Urinary calcium excretion decreases with increasing severity of pregnancy-induced hypertensive disorders, but this trend is not observed in chronic hypertension.

Key Findings

Twenty-one studies were included. Urinary calcium excretion was lower among women with pre-eclampsia than among those with normotensive pregnancies (WMD -158.43, 95% CI -187.95 to -128.92) or chronic hypertension (WMD -92.92, 95% CI -100.55 to -85.29). Excretion was also reduced in severe versus mild pre-eclampsia (WMD -35.00, 95% CI -58.94 to -11.07) and gestational hypertension versus normotensive pregnancies (WMD -50.95, 95% CI -57.74 to -44.17). Calcium excretion was not significantly lower

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population pre
Sample Size See abstract
Age Range See abstract
Condition hypertension

MeSH Terms

  • Calcium
  • Chronic Disease
  • Female
  • Humans
  • Hypertension
  • Hypertension, Pregnancy-Induced
  • Pre-Eclampsia
  • Pregnancy

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Comparative Study, Journal Article, Meta-Analysis, Systematic Review
  • Vertical: calcium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09