n-3 Ingestion may modulate the severity of periodontal disease? Systematic review

source extracted confidence: high 2026-04-09
#diet #dietary-supplements #docosahexaenoic-acids #dose-response-relationship-drug #eicosapentaenoic-acid

n-3 Ingestion may modulate the severity of periodontal disease? Systematic review

Azzi et al., 2018 | Crit Rev Food Sci Nutr | Systematic Review

Citation

Azzi Diana Vilela, Viafara Jesús Alfonso Sánchez, ... Pereira Luciano J. n-3 Ingestion may modulate the severity of periodontal disease? Systematic review. Crit Rev Food Sci Nutr. 2018-Jul-24;58(11):1937-1942. doi:10.1080/10408398.2017.1278677

Abstract

The aim of this study was to determine the effects of n-3 ingestion on periodontal disease. Besides, we also investigated the relationship between plasma concentrations of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and/or aracdonic acid (AA), and periodontal disease. An electronic search was performed in several databases with the following keywords: "n-3," DHA, EPA and polynsaturated fatty acids (PUFA) in combination with the term "periodontal disease" (PD). Only studies conducted with humans, involving clinical parameters of PD assessment and use of n-3 were selected, without restriction to the date of publication. The search has returned 1368 articles, 11 of which were selected. The results were separated according to the type of n-3 ingestion: supplementation or n-3 content in normal diet. In the studies where n-3 has been supplemented, there was no significant difference in the clinical severity of PD compared to the control subjects. However, in patients where levels of n-3 were evaluated in a usual diet, a lower disease severity was reported. We have detected a preventive effect related to plasma levels of EPA and DHA against PD progression. Thus, n-3 ingestion may beneficially interfere in PD progression, depending on the duration and dosage of consumption.

Key Findings

Thus, n-3 ingestion may beneficially interfere in PD progression, depending on the duration and dosage of consumption.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Diet
  • Dietary Supplements
  • Docosahexaenoic Acids
  • Dose-Response Relationship, Drug
  • Eicosapentaenoic Acid
  • Fatty Acids, Omega-3
  • Humans
  • Periodontal Diseases
  • Randomized Controlled Trials as Topic

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: omega-3

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09