Vitamin D status, aeroallergen sensitization, and allergic rhinitis: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#adult #age-factors #air-pollutants #allergens #child

Vitamin D status, aeroallergen sensitization, and allergic rhinitis: A systematic review and meta-analysis

Aryan et al., 2017 | Int Rev Immunol | Meta Analysis

Citation

Aryan Zahra, Rezaei Nima, Camargo Carlos A. Vitamin D status, aeroallergen sensitization, and allergic rhinitis: A systematic review and meta-analysis. Int Rev Immunol. 2017-Jan-02;36(1):41-53. doi:10.1080/08830185.2016.1272600

Abstract

PURPOSE: The role of vitamin D status in the etiology of allergic diseases is uncertain. The aim of this study was to investigate the association of vitamin D status with risk of two main outcomes: aeroallergen sensitization and allergic rhinitis (AR). METHODS: We performed a systematic review of Medline, Scopus, Science Citation Index, and Google Scholar databases. Studies were included if they reported on prevalent or incident cases of aeroallergen sensitization or AR according to vitamin D status. Quality assessment, data extraction and meta-analysis were performed. RESULTS: A total of 21 observational studies were included. Children with serum 25(OH)D ≥75 nmol/L had significantly reduced odds of aeroallergen sensitization, but neither vitamin D intake in pregnancy nor vitamin D supplementation in infancy were associated with risk of AR. Individuals with serum 25(OH)D ≥75 nmol/L had lower prevalence of AR compared to those with serum 25(OH)D <50 nmol/L (OR; 0.71, 95%CI; (0.56-0.89), p = 0.04). This association was mainly observed in adult men; prevalence of AR was lower in men with serum 25(OH)D ≥75 nmol/L compared to men with serum 25(OH)D <50 nmol/L, while this association was not observed in women. CONCLUSIONS: The current literature suggests significant age- and sex-specific relations of vitamin D status to risk of aeroallergen sensitization and AR.

Key Findings

A total of 21 observational studies were included. Children with serum 25(OH)D ≥75 nmol/L had significantly reduced odds of aeroallergen sensitization, but neither vitamin D intake in pregnancy nor vitamin D supplementation in infancy were associated with risk of AR. Individuals with serum 25(OH)D ≥75 nmol/L had lower prevalence of AR compared to those with serum 25(OH)D <50 nmol/L (OR; 0.71, 95%CI; (0.56-0.89), p = 0.04). This association was mainly observed in adult men; prevalence of AR was l

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population adult men
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Age Factors
  • Air Pollutants
  • Allergens
  • Child
  • Humans
  • Immunization
  • Incidence
  • Iran
  • Outcome Assessment, Health Care
  • Prevalence
  • Rhinitis, Allergic
  • Risk
  • Sex Factors
  • Vitamin D

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09