Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

source extracted confidence: high 2026-04-09
#analgesics #biological-products #brain #calcium-channels #central-nervous-system

Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review

Xiao et al., 2016 | Chem Biodivers | Systematic Review

Citation

Xiao Xiao, Wang Xiaoyu, ... Huang Baokang. Natural Flavonoids as Promising Analgesic Candidates: A Systematic Review. Chem Biodivers. 2016-Nov;13(11):1427-1440. doi:10.1002/cbdv.201600060

Abstract

Due to the chemical structural diversity and various analgesic mechanisms, an increasing number of studies indicated that some flavonoids from medicinal plants could be promising candidates for new natural analgesic drugs, which attract high interests of advanced users and academic researchers. The aim of this systematic review is to report flavonoids and its derivatives as new analgesic candidates based on the pharmacological evidences. Sixty-four papers were found concerning the potential analgesic activity of 46 flavonoids. In this case, the evidence for analgesic activity of flavonoids and total flavonoids was investigated. Meanwhile, the corresponding analgesic mechanism of flavonoids was discussed by generalizing and analyzing the current publications. Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development.

Key Findings

Based on this review, the conclusion can be drawn that some flavonoids are promising candidates for painful conditions and deserve particular attention in further research and development.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Analgesics
  • Biological Products
  • Brain
  • Calcium Channels
  • Central Nervous System
  • Flavonoids
  • Humans
  • Nitric Oxide
  • Prostaglandins
  • Serotonin

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: quercetin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09