Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis

source extracted confidence: high 2026-04-09
#antioxidants #ascorbic-acid #beta-cryptoxanthin #carotenoids #databases-factual

Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis

Chen et al., 2016 | Int J Food Sci Nutr | Meta Analysis

Citation

Chen Jiamin, Jiang Wuxia, ... Cai Jianting. Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis. Int J Food Sci Nutr. 2016-Nov;67(7):744-53. doi:10.1080/09637486.2016.1197892

Abstract

We conducted a meta-analysis to systematically evaluate the association between antioxidants intake and pancreatic cancer risk. Relevant articles were retrieved from PUBMED and EMBASE databases and standard meta-analysis methods were applied. Finally a total of 18 studies were included. Comparing the highest with lowest categories, higher dietary intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were significantly associated with reduced pancreatic cancer risk (for selenium, pooled OR = 0.47, 95%CI 0.26-0.85; for vitamin C, pooled OR = 0.68, 95%CI 0.57-0.80; for vitamin E, pooled OR = 0.70, 95%CI 0.62-0.81; for β-carotene, pooled OR = 0.74, 95%CI 0.56-0.98; for β-cryptoxanthin, pooled OR = 0.70, 95%CI 0.56-0.88). Lycopene intake was marginally associated with pancreatic cancer risk (pooled OR = 0.85, 95%CI 0.73-1.00), while no significant association was observed for α-carotene, lutein and zeaxanthin. In summary, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk.

Key Findings

In summary, higher dietary intake of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin was inversely associated with pancreatic cancer risk.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 18
Age Range See abstract
Condition See abstract

MeSH Terms

  • Antioxidants
  • Ascorbic Acid
  • Beta-Cryptoxanthin
  • Carotenoids
  • Databases, Factual
  • Diet
  • Humans
  • Lutein
  • Lycopene
  • Pancreatic Neoplasms
  • Risk Factors
  • Selenium
  • Vitamin E
  • Zeaxanthins
  • beta Carotene

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: vitamin-c

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09