Integrative Multivariate Logistic Regression Analysis of Risk Factors for Kashin-Beck disease

source extracted confidence: high 2026-04-09
#age-of-onset #female #food-contamination #food-preferences #hair

Integrative Multivariate Logistic Regression Analysis of Risk Factors for Kashin-Beck disease

Yu et al., 2016 | Biol Trace Elem Res | Meta Analysis

Citation

Yu Fang-Fang, Liu Huan, Guo Xiong. Integrative Multivariate Logistic Regression Analysis of Risk Factors for Kashin-Beck disease. Biol Trace Elem Res. 2016-Dec;174(2):274-279

Abstract

To determine the current evidence on risk factors for Kashin-Beck disease (KBD) using an integrative meta-analysis. We searched five English and three Chinese databases from inception to September 2015, to identify case-control studies that examined risk factors for KBD using multivariate logistic analysis. DerSimonian and Laird effective models are applied in processing data using pooled odds ratios (ORs) and 95 % confidence intervals (CI). Seven studies were identified with 3087 cases and 6402 controls. The main risk factors found to be significantly associated with the onset of KBD were age (OR 1.19, 95 % CI 1.10-1.28), parents prevalence (OR 5.16, 2.51-7.80), family hygiene (OR 1.68, 1.42-1.93), food source (OR 3.29, 2.38-4.19), wheat (OR 1.12, 1.08-1.16), wheat germ necrosis rate (OR 6.03, 1.87-12.92), total volatile basic nitrogen (OR 6.85, 1.01-28.67), low selenium in hair (OR 2.29, 1.08-3.50) were found to be significant risks factors. The pooled ORs (95 % CI) of protein intake and rice were 0.79 (0.66-0.93) and 0.90 (0.86-0.95), respectively, indicating that the two factors may be protective for KBD. We found that the combination of low protein intake, polluted grain, and selenium deficiency may contribute to be onset of KBD together.

Key Findings

We found that the combination of low protein intake, polluted grain, and selenium deficiency may contribute to be onset of KBD together.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition deficiency

MeSH Terms

  • Age of Onset
  • Female
  • Food Contamination
  • Food Preferences
  • Hair
  • Humans
  • Kashin-Beck Disease
  • Logistic Models
  • Male
  • Nitrogen
  • Protein Deficiency
  • Risk Factors
  • Selenium

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: selenium

Provenance

  • PMID: 27113769
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09