Parenteral trace element provision: recent clinical research and practical conclusions

Stehle et al., 2016 | Eur J Clin Nutr | Systematic Review

Citation

Stehle P, Stoffel-Wagner B, Kuhn K S. Parenteral trace element provision: recent clinical research and practical conclusions. Eur J Clin Nutr. 2016-Aug;70(8):886-93. doi:10.1038/ejcn.2016.53

Abstract

The aim of this systematic review (PubMed, www.ncbi.nlm.nih.gov/pubmed and Cochrane, www.cochrane.org; last entry 31 December 2014) was to present data from recent clinical studies investigating parenteral trace element provision in adult patients and to draw conclusions for clinical practice. Important physiological functions in human metabolism are known for nine trace elements: selenium, zinc, copper, manganese, chromium, iron, molybdenum, iodine and fluoride. Lack of, or an insufficient supply of, these trace elements in nutrition therapy over a prolonged period is associated with trace element deprivation, which may lead to a deterioration of existing clinical symptoms and/or the development of characteristic malnutrition syndromes. Therefore, all parenteral nutrition prescriptions should include a daily dose of trace elements. To avoid trace element deprivation or imbalances, physiological doses are recommended.

Key Findings

To avoid trace element deprivation or imbalances, physiological doses are recommended.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	adult patients
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Adult
Chromium
Copper
Fluorides
Humans
Iodine
Iron
Manganese
Molybdenum
Nutritional Requirements
Parenteral Nutrition
Selenium
Trace Elements
Zinc

Evidence Classification

Level: Systematic Review
Publication Types: Journal Article, Systematic Review
Vertical: iodine

Provenance

PMID: 27049031
DOI: 10.1038/ejcn.2016.53
PMCID: PMC5399133
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09