[The diagnostic value of serum PABA determination in pancreatic disease and in relation to anticholinergic medication]

source extracted confidence: high 2026-04-09
#4-aminobenzoic-acid #adult #cholecystokinin #dose-response-relationship-drug #exocrine-pancreatic-insufficiency

[The diagnostic value of serum PABA determination in pancreatic disease and in relation to anticholinergic medication]

von et al., 1989 | Gastroenterol J | Rct

Citation

von Kleist D, Rössler W, ... Hampel K E. [The diagnostic value of serum PABA determination in pancreatic disease and in relation to anticholinergic medication]. Gastroenterol J. 1989;49(3):108-12

Abstract

PABA-serum and urine-concentration were studied in patients with normal, pathologic and pharmacologically inhibited pancreatic function. Secretin-pancreozymine test was selected as reference method. In patients with normal pancreas function and volunteers, PABA-serum-concentration was characterized by a rapid increase during the first 1 1/2 hours. A maximum increase of 32.42 +/- 10.04 mumol/l was reached after 90 minutes. In patients with exocrine pancrease insufficiency, difference to the control group was greatest after 30, 60, 90, and 120 min. Pharmacologic inhibition of the exocrine pancreas using pirenzepine also resulted in a significantly reduced PABA-serum-concentration after 30, 60 and 90 min. In correspondence to the delayed and smaller serum PABA increase, urine-PABA-concentrations were also diminished. Our results indicate that the optimal interval to differentiate between normal and impaired pancreas function with use of serum PABA determination is at 90 min after test begin.

Key Findings

Our results indicate that the optimal interval to differentiate between normal and impaired pancreas function with use of serum PABA determination is at 90 min after test begin.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population normal
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • 4-Aminobenzoic Acid
  • Adult
  • Cholecystokinin
  • Dose-Response Relationship, Drug
  • Exocrine Pancreatic Insufficiency
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatic Function Tests
  • Pirenzepine
  • Randomized Controlled Trials as Topic
  • Ranitidine
  • Secretin

Evidence Classification

  • Level: Rct
  • Publication Types: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial
  • Vertical: paba

Provenance

  • PMID: 2698170
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-12 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-12