Magnesium status and the metabolic syndrome: A systematic review and meta-analysis

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#humans #magnesium #metabolic-syndrome #observational-studies-as-topic #risk-factors

Magnesium status and the metabolic syndrome: A systematic review and meta-analysis

Sarrafzadegan et al., 2016 | Nutrition | Meta Analysis

Citation

Sarrafzadegan Nizal, Khosravi-Boroujeni Hossein, ... Salehi-Abargouei Amin. Magnesium status and the metabolic syndrome: A systematic review and meta-analysis. Nutrition. 2016-Apr;32(4):409-17. doi:10.1016/j.nut.2015.09.014

Abstract

OBJECTIVES: To systematically review the published evidence regarding the association between Mg intake and serum concentrations with MetS and, if possible, to summarize the results using a meta-analysis. METHODS: PubMed, ISI Web of Science, Scopus, and Google Scholar were searched to identify related articles. Fully adjusted odds ratios (ORs) of MetS in participants with the highest intake of Mg compared with those who had the least consumption, and the mean difference in serum Mg levels between patients with MetS and their controls were extracted for the meta-analysis. RESULTS: In total, 9 articles with 31 876 participants were included in the meta-analysis regarding the association between dietary Mg intake and MetS, and 8 studies that assessed the mean level of serum Mg in 3487 individuals with and without MetS were eligible. Our analysis found that higher consumption of Mg is associated with lower risk of MetS (OR = 0.73; 95% confidence interval: 0.62, 0.86; P < 0.001); we also could find a significant but heterogeneous association between serum Mg and MetS (mean difference: -0.19; 95% confidence interval: -0.36, 0.03; P = 0.023). CONCLUSIONS: The present systematic review and meta-analysis found an inverse association between Mg intake and MetS. However, the inverse association for serum Mg levels was highly heterogeneous and sensitive. The link between Mg status and MetS should be confirmed by prospective cohort studies controlling the association for other nutrients related to MetS risk.

Key Findings

In total, 9 articles with 31 876 participants were included in the meta-analysis regarding the association between dietary Mg intake and MetS, and 8 studies that assessed the mean level of serum Mg in 3487 individuals with and without MetS were eligible. Our analysis found that higher consumption of Mg is associated with lower risk of MetS (OR = 0.73; 95% confidence interval: 0.62, 0.86; P < 0.001); we also could find a significant but heterogeneous association between serum Mg and MetS (mean di

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population mets and their controls
Sample Size 876
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Magnesium
  • Metabolic Syndrome
  • Observational Studies as Topic
  • Risk Factors

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: magnesium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09