Takotsubo cardiomyopathy systematic review: Pathophysiologic process, clinical presentation and diagnostic approach to Takotsubo cardiomyopathy
Takotsubo cardiomyopathy systematic review: Pathophysiologic process, clinical presentation and diagnostic approach to Takotsubo cardiomyopathy
Ono et al., 2016 | Int J Cardiol | Systematic Review
Citation
Ono Ryohei, Falcão L Menezes. Takotsubo cardiomyopathy systematic review: Pathophysiologic process, clinical presentation and diagnostic approach to Takotsubo cardiomyopathy. Int J Cardiol. 2016-Apr-15;209:196-205. doi:10.1016/j.ijcard.2016.02.012
Abstract
Takotsubo cardiomyopathy (TTC) is characterized by transient left ventricular apical ballooning with the absence of coronary occlusion, which typically occurs in older women after emotional or physical stress. The pathophysiology of TTC is not well established, though several possible causes such as catecholamine cardiotoxicity, metabolic disturbance, coronary microvascular impairment and multivessel epicardial coronary artery spasm have been proposed. A number of diagnostic criteria have been suggested in the world and not unified as single, but the most common accepted one is Mayo Clinic proposed criteria. Since the clinical presentation of TTC is usually similar to acute coronary syndrome, differential diagnosis is essential to exclude other diseases and also for its treatment. Imaging modality including echocardiogram, angio CT and cardiac MRI, and lab tests for catecholamine, troponin T, creatine kinase MB and B-type natriuretic peptide can be useful to differentiate TTC from other diseases. Prognosis is generally favorable and in-hospital mortality is from 0% to within 10%.
Key Findings
Prognosis is generally favorable and in-hospital mortality is from 0% to within 10%.
Outcomes Measured
- Requires manual extraction
Population
| Field | Value |
|---|---|
| Population | older women |
| Sample Size | See abstract |
| Age Range | See abstract |
| Condition | stress |
MeSH Terms
- Biomarkers
- Catecholamines
- Diagnosis, Differential
- Female
- Humans
- Male
- Sex Characteristics
- Takotsubo Cardiomyopathy
Evidence Classification
- Level: Systematic Review
- Publication Types: Journal Article, Systematic Review
- Vertical: creatine
Provenance
- PMID: 26896623
- DOI: 10.1016/j.ijcard.2016.02.012
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09