The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis

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#aged #anti-inflammatory-agents-non-steroidal #antioxidants #female #follow-up-studies

The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis

Ghoochani et al., 2016 | J Sci Food Agric | Rct

Citation

Ghoochani Nasrin, Karandish Majid, ... Jalali Mohammad Taha. The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis. J Sci Food Agric. 2016-Oct;96(13):4377-81. doi:10.1002/jsfa.7647

Abstract

BACKGROUND: Osteoarthritis (OA) is one of the commonest forms of musculoskeletal disorders that leads to joint degeneration and has a major impact on patients' quality of life. Experimental and in vitro studies have suggested the protective roles of pomegranate juice (PJ) as a rich antioxidant source for mitigating cartilage inflammation. In this interventional study, 38 patients with knee OA were randomly divided into two groups: PJ or control for 6 weeks to evaluate the effect of this intervention on clinical signs, inflammation and antioxidant status. RESULTS: Significant decreases in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) total score (P = 0.01), stiffness score (P = 0.00) and physical function score (P = 0.01) were observed in PJ group after the intervention. The means of serum levels of matrix metalloproteinase (MMP)-13 was significantly decreased (P = 0.02) and glutathione peroxidase was increased in the intervention group compared with the control group after the study period (P = 0.02). CONCLUSIONS: According to the findings of this clinical trial, PJ consumption can improve physical function and stiffness, decrease breakdown cartilage enzymes and increase antioxidant status in patients with knee OA. © 2016 Society of Chemical Industry.

Key Findings

Significant decreases in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) total score (P = 0.01), stiffness score (P = 0.00) and physical function score (P = 0.01) were observed in PJ group after the intervention. The means of serum levels of matrix metalloproteinase (MMP)-13 was significantly decreased (P = 0.02) and glutathione peroxidase was increased in the intervention group compared with the control group after the study period (P = 0.02).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population knee oa were randomly
Sample Size 38
Age Range See abstract
Condition inflammation

MeSH Terms

  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Female
  • Follow-Up Studies
  • Fruit and Vegetable Juices
  • Glutathione Peroxidase
  • Humans
  • Iran
  • Knee Joint
  • Lythraceae
  • Male
  • Matrix Metalloproteinase 1
  • Matrix Metalloproteinase 13
  • Middle Aged
  • Osteoarthritis, Knee
  • Oxidative Stress
  • Pain Measurement
  • Self Report
  • Severity of Illness Index

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: pomegranate

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09