Coenzyme Q10 Supplementation and Exercise in Healthy Humans: A Systematic Review

source extracted confidence: high 2026-04-09
#antioxidants #dietary-supplements #energy-metabolism #exercise #exercise-tolerance

Coenzyme Q10 Supplementation and Exercise in Healthy Humans: A Systematic Review

Sarmiento et al., 2016 | Curr Drug Metab | Systematic Review

Citation

Sarmiento Alvaro, Diaz-Castro Javier, ... Ochoa Julio J. Coenzyme Q10 Supplementation and Exercise in Healthy Humans: A Systematic Review. Curr Drug Metab. 2016;17(4):345-58

Abstract

OBJECTIVE: Coenzyme Q10 (CoQ10) is an endogenous lipid-soluble benzoquinone compound that functions as a diffusible electron carrier in the electron transport chain. It is prevalent in all human tissues and organs, although it is mainly biosynthesised and concentrated in tissues with high energy turnover. The aim of this review was to perform an exhaustive analysis of the influence and effects of CoQ10 supplementation on parameters related to exercise in healthy humans, and to clarify the current state of knowledge of this field of study, presenting the relevant data in a systematic manner. METHOD: This paper describes a transversal descriptive systematic review of published research in this field; the study was conducted using a method adapted from the PRISMA guidelines. The inclusion criteria applied were based on the PICO (population, intervention, comparison, and outcome) model. RESULTS: The database search performed yielded 372 citations. Finally, 13 studies met all the inclusion criteria and were incorporated in the present review. CONCLUSION: CoQ10 has properties related to bioenergetic and antioxidant activity; thus, it is intimately involved in energy production and in the prevention of peroxidative damage to membrane phospholipids and of free radical-induced oxidation. These properties make it suitable as a dietary supplement to improve cellular bioenergetics and to inhibit certain age-related pathologies.

Key Findings

The database search performed yielded 372 citations. Finally, 13 studies met all the inclusion criteria and were incorporated in the present review.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population healthy humans
Sample Size 13
Age Range See abstract
Condition See abstract

MeSH Terms

  • Antioxidants
  • Dietary Supplements
  • Energy Metabolism
  • Exercise
  • Exercise Tolerance
  • Humans
  • Non-Randomized Controlled Trials as Topic
  • Oxidative Stress
  • Randomized Controlled Trials as Topic
  • Ubiquinone
  • Vitamins

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: coq10

Provenance

  • PMID: 26526835
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09