Caffeine and Progression of Parkinson Disease: A Deleterious Interaction With Creatine

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#caffeine #central-nervous-system-stimulants #creatine #disease-progression #drug-interactions

Caffeine and Progression of Parkinson Disease: A Deleterious Interaction With Creatine

Simon et al., 2015 | Clin Neuropharmacol | Rct

Citation

Simon David K, Wu Cai, ... Wong Pei Shieen. Caffeine and Progression of Parkinson Disease: A Deleterious Interaction With Creatine. Clin Neuropharmacol. 2015;38(5):163-9. doi:10.1097/WNF.0000000000000102

Abstract

OBJECTIVE: Increased caffeine intake is associated with a lower risk of Parkinson disease (PD) and is neuroprotective in mouse models of PD. However, in a previous study, an exploratory analysis suggested that, in patients taking creatine, caffeine intake was associated with a faster rate of progression. In the current study, we investigated the association of caffeine with the rate of progression of PD and the interaction of this association with creatine intake. METHODS: Data were analyzed from a large phase 3 placebo-controlled clinical study of creatine as a potentially disease-modifying agent in PD. Subjects were recruited for this study from 45 movement disorders centers across the United States and Canada. A total of 1741 subjects with PD participated in the primary clinical study, and caffeine intake data were available for 1549 of these subjects. The association of caffeine intake with rate of progression of PD as measured by the change in the total Unified Parkinson Disease Rating Scale score and the interaction of this association with creatine intake were assessed. RESULTS: Caffeine intake was not associated with the rate of progression of PD in the main analysis, but higher caffeine intake was associated with significantly faster progression among subjects taking creatine. CONCLUSIONS: This is the largest and longest study conducted to date that addresses the association of caffeine with the rate of progression of PD. These data indicate a potentially deleterious interaction between caffeine and creatine with respect to the rate of progression of PD.

Key Findings

Caffeine intake was not associated with the rate of progression of PD in the main analysis, but higher caffeine intake was associated with significantly faster progression among subjects taking creatine.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population pd participated in the
Sample Size 1741
Age Range See abstract
Condition See abstract

MeSH Terms

  • Caffeine
  • Central Nervous System Stimulants
  • Creatine
  • Disease Progression
  • Drug Interactions
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease

Evidence Classification

  • Level: Rct
  • Publication Types: Clinical Trial, Phase III, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
  • Vertical: creatine-neurological

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09