A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles

source extracted confidence: high 2026-04-09
#antithrombins #blood-coagulation #blood-coagulation-tests #cross-over-studies #double-blind-method

A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles

Kurosawa et al., 2015 | Sci Rep | Rct

Citation

Kurosawa Yuko, Nirengi Shinsuke, ... Hamaoka Takafumi. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep. 2015-Jun-25;5:11601. doi:10.1038/srep11601

Abstract

Our aim was to determine the quantitative effects of a single-dose of Nattokinase (NK) administration on coagulation/fibrinolysis parameters comprehensively in healthy male subjects. A double-blind, placebo-controlled cross-over NK intervention study was carried out in 12 healthy young males. Following the baseline blood draw, each subject was randomized to receive either a single-dose of 2,000 FU NK (NSK-SD, Japan Bio Science Laboratory Co., Ltd) or placebo with subsequent cross-over of the groups. Subjects donated blood samples at 2, 4, 6 and 8 hours following administration for analysis of coagulation/fibrinolysis parameters. As a result, D-dimer concentrations at 6, and 8 hours, and blood fibrin/fibrinogen degradation products at 4 hours after NK administration elevated significantly (p < 0.05, respectively). Factor VIII activity declined at 4 and 6 hours (p < 0.05, respectively), blood antithrombin concentration was higher at 2 and 4 hours (p < 0.05, respectively), and the activated partial thromboplastin time prolonged significantly at 2 and 4 hours following NK administration (p < 0.05 and p < 0.01, respectively). All the changes, however, were within the normal range. In conclusion, thus, a single-dose of NK administration appears enhancing fibrinolysis and anti-coagulation via several different pathways simultaneously.

Key Findings

In conclusion, thus, a single-dose of NK administration appears enhancing fibrinolysis and anti-coagulation via several different pathways simultaneously.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population healthy male
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Antithrombins
  • Blood Coagulation
  • Blood Coagulation Tests
  • Cross-Over Studies
  • Double-Blind Method
  • Factor VIII
  • Fibrin
  • Fibrin Fibrinogen Degradation Products
  • Fibrinogen
  • Fibrinolysis
  • Fibrinolytic Agents
  • Humans
  • Male
  • Partial Thromboplastin Time
  • Subtilisins
  • Time Factors

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
  • Vertical: nattokinase

Provenance

Source extracted via PubMed E-utilities API on 2026-04-12