Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients

source extracted confidence: high 2026-04-09
#adult #aged #arginine #blood-glucose #c-reactive-protein

Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients

Imani et al., 2015 | Nutrition | Rct

Citation

Imani Hossein, Tabibi Hadi, ... Rahmani Leila. Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients. Nutrition. 2015-May;31(5):703-7. doi:10.1016/j.nut.2014.11.020

Abstract

OBJECTIVE: The aim of this study was to investigate the effects of ginger supplementation on serum glucose, advanced glycation end products, oxidative stress, and systemic and vascular inflammatory markers in patients on peritoneal dialysis (PD). METHODS: In this randomized, double-blind, placebo-controlled trial, 36 patients on PD were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 1000 mg/d ginger for 10 wk, whereas the placebo group received corresponding placebos. At baseline and the end of week 10, serum concentrations of glucose, carboxymethyl lysine, pentosidine, malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), soluble intercellular adhesion molecule type 1 (sICAM-1), soluble vascular cell adhesion molecule type 1 (sVCAM-1), and sE-selectin were measured after a 12- to 14-h fast. RESULTS: Serum fasting glucose decreased significantly up to 20% in the ginger group at the end of week 10 compared with baseline (P < 0.05), and the reduction was significant in comparison with the placebo group (P < 0.05). There were no significant differences between the two groups in mean changes of serum carboxymethyl lysine, pentosidine, MDA, hs-CRP, sICAM-1, sVCAM-1, and sE-selectin. CONCLUSION: This study indicated that daily administration of 1000 mg ginger reduces serum fasting glucose, which is a risk factor for hyperinsulinemia, dyslipidemia, peritoneal membrane fibrosis, and cardiovascular disease, in patients on PD.

Key Findings

Serum fasting glucose decreased significantly up to 20% in the ginger group at the end of week 10 compared with baseline (P < 0.05), and the reduction was significant in comparison with the placebo group (P < 0.05). There were no significant differences between the two groups in mean changes of serum carboxymethyl lysine, pentosidine, MDA, hs-CRP, sICAM-1, sVCAM-1, and sE-selectin.

Outcomes Measured

  • C-reactive protein
  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 36
Age Range See abstract
Condition stress

MeSH Terms

  • Adult
  • Aged
  • Arginine
  • Blood Glucose
  • C-Reactive Protein
  • Dietary Supplements
  • Double-Blind Method
  • E-Selectin
  • Female
  • Zingiber officinale
  • Glycation End Products, Advanced
  • Humans
  • Inflammation
  • Intercellular Adhesion Molecule-1
  • Kidney Failure, Chronic
  • Lysine
  • Male
  • Malondialdehyde
  • Middle Aged
  • Peritoneal Dialysis
  • Treatment Outcome
  • Vascular Cell Adhesion Molecule-1

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
  • Vertical: ginger

Provenance

Source extracted via PubMed E-utilities API on 2026-04-10