Efficacy and safety of perindopril arginine + amlodipine in hypertension
Efficacy and safety of perindopril arginine + amlodipine in hypertension
Elliott et al., 2015 | J Am Soc Hypertens | Rct
Citation
Elliott William J, Whitmore Jennifer, ... Bakris George L. Efficacy and safety of perindopril arginine + amlodipine in hypertension. J Am Soc Hypertens. 2015-Apr;9(4):266-74. doi:10.1016/j.jash.2015.01.012
Abstract
To study the efficacy and safety of a new combination of perindopril arginine and amlodipine besylate, 837 subjects were enrolled in a three-arm, prospective, 59-center, randomized clinical trial. For 42 days, subjects (average seated blood pressure [BP], 158 ± 12/101 ± 5 mm Hg; age, 52 ± 10 years; 52% male; 34% black; 20% diabetic) received amlodipine/perindopril arginine (10/14 mg/d), perindopril erbumine (16 mg/d), or amlodipine (10 mg/d). Goal BP was <140/90 or <130/80 mm Hg in diabetics, per JNC 7 guidelines. The combination showed the largest change in seated BP (-23.7/-15.7 vs. -13.7/-9.5 vs. -19.3/-13.2 mm Hg, respectively; P < .0001), the highest proportion at goal BP (51% vs. 26% vs. 37%; P < .0001), and a lower incidence of pedal edema and adverse events compared with amlodipine. No deaths or significant differences across groups in early discontinuation, serum potassium, or rates of total or serious adverse events or glomerular filtration, were observed.
Key Findings
No deaths or significant differences across groups in early discontinuation, serum potassium, or rates of total or serious adverse events or glomerular filtration, were observed.
Outcomes Measured
- blood pressure
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | 837 |
| Age Range | See abstract |
| Condition | blood pressure |
MeSH Terms
- Amlodipine
- Antihypertensive Agents
- Diabetes Mellitus
- Double-Blind Method
- Drug Therapy, Combination
- Edema
- Female
- Glomerular Filtration Rate
- Humans
- Hypertension
- Male
- Middle Aged
- Perindopril
- Potassium
- Prospective Studies
Evidence Classification
- Level: Rct
- Publication Types: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- Vertical: arginine-cardiovascular
Provenance
- PMID: 25804495
- DOI: 10.1016/j.jash.2015.01.012
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09