Blood reflects tissue oxidative stress: a systematic review
Blood reflects tissue oxidative stress: a systematic review
Margaritelis et al., 2015 | Biomarkers | Systematic Review
Citation
Margaritelis Nikos V, Veskoukis Aristidis S, ... Nikolaidis Michalis G. Blood reflects tissue oxidative stress: a systematic review. Biomarkers. 2015-Mar;20(2):97-108. doi:10.3109/1354750X.2014.1002807
Abstract
We examined whether the levels of oxidative stress biomarkers measured in blood reflect the tissue redox status. Data from studies that measured redox biomarkers in blood, heart, liver, kidney and skeletal muscle were analyzed. In seven out of nine investigated redox biomarkers (malondialdehyde, reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, vitamin C and E) there was generally good qualitative and quantitative agreement between the blood and tissues. In contrast, oxidized glutathione and the reduced to oxidized glutathione ratio showed poor agreement between the blood and tissues. This study suggests that most redox biomarkers measured in blood adequately reflect tissue redox status.
Key Findings
This study suggests that most redox biomarkers measured in blood adequately reflect tissue redox status.
Outcomes Measured
- Requires manual extraction
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | See abstract |
| Age Range | See abstract |
| Condition | stress |
MeSH Terms
- Animals
- Biomarkers
- Humans
- Kidney
- Liver
- Muscle, Skeletal
- Myocardium
- Oxidation-Reduction
- Oxidative Stress
- Species Specificity
Evidence Classification
- Level: Systematic Review
- Publication Types: Journal Article, Systematic Review
- Vertical: vitamin-c
Provenance
- PMID: 25582635
- DOI: 10.3109/1354750X.2014.1002807
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09