Association of vitamin D receptor gene polymorphism with the urine calcium level in nephrolithiasis patients

source extracted confidence: high 2026-04-09
#alleles #calcium #genetic-association-studies #genetic-predisposition-to-disease #genotype

Association of vitamin D receptor gene polymorphism with the urine calcium level in nephrolithiasis patients

Zhou et al., 2015 | J Recept Signal Transduct Res | Meta Analysis

Citation

Zhou Tian-Biao, Jiang Zong-Pei, ... Zhang Rui. Association of vitamin D receptor gene polymorphism with the urine calcium level in nephrolithiasis patients. J Recept Signal Transduct Res. 2015-Apr;35(2):127-32. doi:10.3109/10799893.2014.936462

Abstract

Association of vitamin D receptor (VDR) gene polymorphism with the urine calcium level in nephrolithiasis patients from the published reports are still conflicting. This study was conducted to evaluate the relationship between VDR BsmI (rs1544410), Fok1 (rs2228570), TaqI (rs731236) and ApaI (rs7975232) gene polymorphism and urine calcium level in nephrolithiasis patients using meta-analysis method. The association studies were identified from PubMed, and Cochrane Library on 1 April 2014, and eligible investigations were included and synthesized using meta-analysis method. Four reports were recruited into this meta-analysis for the association of VDR BsmI, Fok1, TaqI and ApaI gene polymorphism with urine calcium level in nephrolithiasis patients. In this meta-analysis, VDR BsmI B allele and BB genotype, Fok1 f allele and ff genotype, TaqI, and ApaI gene polymorphism were not associated with urine calcium level in nephrolithiasis patients. However, the BsmI bb genotype and Fok1 FF genotype were associated with the urine calcium level in nephrolithiasis patients. In conclusion, VDR BsmI bb genotype and Fok1 FF genotype were associated with the urine calcium level in nephrolithiasis patients. However, more studies should be conducted to confirm it.

Key Findings

However, more studies should be conducted to confirm it.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Alleles
  • Calcium
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Nephrolithiasis
  • Receptors, Calcitriol
  • Risk Factors

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't
  • Vertical: calcium-kidney

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09