Flavonoids and immune function in human: a systematic review
Flavonoids and immune function in human: a systematic review
Peluso et al., 2015 | Crit Rev Food Sci Nutr | Systematic Review
Citation
Peluso Ilaria, Miglio Cristiana, ... Serafini Mauro. Flavonoids and immune function in human: a systematic review. Crit Rev Food Sci Nutr. 2015;55(3):383-95. doi:10.1080/10408398.2012.656770
Abstract
Flavonoids, through a modulation of immune function, have been suggested to be involved in the role played by plant foods in disease prevention. We performed a systematic search in the MEDLINE database to review the effect of flavonoid-rich foods and flavonoids supplements on immune function. A total of 58 studies, were identified as suitable: 41 addressed in vivo proinflammatory cytokines and 15 measured ex vivo markers of immune function. According to our findings and on the basis of single food items, the number of studies in humans is limited and, for galenic supplements, only quercetin has been investigated. More evidences are needed to clarify the role of flavonoids as modulator of immune function in humans.
Key Findings
More evidences are needed to clarify the role of flavonoids as modulator of immune function in humans.
Outcomes Measured
- inflammatory markers
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | 58 |
| Age Range | See abstract |
| Condition | See abstract |
MeSH Terms
- Cytokines
- Dietary Supplements
- Flavonoids
- Humans
- Inflammation
- Plant Extracts
- Quercetin
Evidence Classification
- Level: Systematic Review
- Publication Types: Journal Article, Systematic Review
- Vertical: quercetin
Provenance
- PMID: 24915384
- DOI: 10.1080/10408398.2012.656770
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09