Omega-3 fatty acids for postoperative atrial fibrillation: alone or in combination with antioxidant vitamins?

source extracted confidence: high 2026-04-09
#antioxidants #ascorbic-acid #atrial-fibrillation #cardiac-surgical-procedures #fatty-acids-omega-3

Omega-3 fatty acids for postoperative atrial fibrillation: alone or in combination with antioxidant vitamins?

Guo et al., 2014 | Heart Lung Circ | Meta Analysis

Citation

Guo Xue-Yuan, Yan Xian-Liang, ... Ma Chang-Sheng. Omega-3 fatty acids for postoperative atrial fibrillation: alone or in combination with antioxidant vitamins?. Heart Lung Circ. 2014-Aug;23(8):743-50. doi:10.1016/j.hlc.2014.02.018

Abstract

BACKGROUND: The effects of omega-3 polyunsaturated fatty acids (PUFA) on the prevention of postoperative atrial fibrillation (POAF) are inconclusive in current studies. Moreover, the most appropriate composition of PUFA to play the protective role is unclear. The aim of this meta-analysis was to ascertain the protective role of PUFA on POAF and the most appropriate composition. METHODS: Studies were identified through PubMed, CENTRAL, EMBASE, reviews and reference lists of relevant papers. The odds ratio (OR) was calculated for POAF. Statistical analyses were performed with Review Manager 5.0. RESULTS: Eleven randomised controlled trials with 3137 patients were included in the analysis. The use of PUFA alone did not reduce the incidence of POAF compared with the control (OR: 0.76; 95% confidence interval [CI]: 0.57-1.03; P=0.08; I(2)=52%). However, combination therapy with PUFA and vitamins C and E reduced the incidence of POAF by 68% (OR: 0.32; 95%CI: 0.17-0.60; P=0.0005; I(2)=38%). Subgroup analysis indicated that the ratio of EPA/DHA 1:2 was effective in preventing POAF (OR: 0.35; 95%CI: 0.24-0.50; P<0.00001; I(2)=0%), while the ratio not 1:2 failed. CONCLUSIONS: Combination therapy with PUFA and vitamins C and E is effective in the prevention of POAF while PUFA alone is not. The ratio of EPA/DHA may influence the incidence of POAF, and 1:2 may be most appropriate. Studies about PUFA on the prevention of POAF are still worthwhile to be conducted in the future.

Key Findings

Eleven randomised controlled trials with 3137 patients were included in the analysis. The use of PUFA alone did not reduce the incidence of POAF compared with the control (OR: 0.76; 95% confidence interval [CI]: 0.57-1.03; P=0.08; I(2)=52%). However, combination therapy with PUFA and vitamins C and E reduced the incidence of POAF by 68% (OR: 0.32; 95%CI: 0.17-0.60; P=0.0005; I(2)=38%). Subgroup analysis indicated that the ratio of EPA/DHA 1:2 was effective in preventing POAF (OR: 0.35; 95%CI: 0.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 3137
Age Range See abstract
Condition See abstract

MeSH Terms

  • Antioxidants
  • Ascorbic Acid
  • Atrial Fibrillation
  • Cardiac Surgical Procedures
  • Fatty Acids, Omega-3
  • Female
  • Humans
  • Male
  • Postoperative Complications
  • PubMed
  • Randomized Controlled Trials as Topic
  • Vitamin E
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review
  • Vertical: omega-3

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09