Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials

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#cardiovascular-diseases #cholesterol #cholesterol-hdl #cholesterol-ldl #humans

Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials

Sahebkar et al., 2013 | Nutr Rev | Meta Analysis

Citation

Sahebkar Amirhossein. Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2013-Dec;71(12):822-35. doi:10.1111/nure.12081

Abstract

A systematic review and meta-analysis of available evidence was conducted to obtain a conclusive result on the lipid-modulating effects of resveratrol. Seven randomized controlled trials with a total of 282 subjects (141 in each group) met the eligibility criteria. Overall, resveratrol supplementation had no significant effect on any of the lipid parameters assessed: total cholesterol (weighted mean difference [WMD] -8.70; 95% confidence interval [95% CI] -21.54-4.14; P = 0.18), low-density lipoprotein cholesterol (WMD -3.22; 95% CI -12.56-6.12); P = 0.50), high-density lipoprotein cholesterol (WMD -0.26; 95% CI -4.25-3.73; P = 0.90), and triglycerides (WMD -4.30; 95% CI -20.22-11.63; P = 0.60). These results were robust in sensitivity analysis and were not dependent on the resveratrol dose, the duration of supplementation, or the cardiovascular risk status of the population studied. While future large-scale, well-designed trials are warranted, the current evidence suggests that mechanisms other than hypolipidemic effects account for the established cardioprotective properties of resveratrol.

Key Findings

While future large-scale, well-designed trials are warranted, the current evidence suggests that mechanisms other than hypolipidemic effects account for the established cardioprotective properties of resveratrol.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 282
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cardiovascular Diseases
  • Cholesterol
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Humans
  • Lipid Metabolism
  • Lipids
  • Randomized Controlled Trials as Topic
  • Resveratrol
  • Risk Factors
  • Stilbenes
  • Triglycerides

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09