Animal models of the serotonin syndrome: a systematic review

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#animals #disease-models-animal #humans #mice #rats

Animal models of the serotonin syndrome: a systematic review

Haberzettl et al., 2013 | Behav Brain Res | Systematic Review

Citation

Haberzettl Robert, Bert Bettina, ... Fox Meredith A. Animal models of the serotonin syndrome: a systematic review. Behav Brain Res. 2013-Nov-01;256:328-45. doi:10.1016/j.bbr.2013.08.045

Abstract

The serotonin syndrome (SS) is a potentially life-threatening disorder in humans which is induced by ingestion of an overdose or by combination of two or more serotonin (5-HT)-enhancing drugs. In animals, acute administration of direct and indirect 5-HT agonists also leads to a set of behavioral and autonomic responses. In the current review, we provide an overview of the existing versions of the animal model of the SS. With a focus on studies in rats and mice, we analyze the frequency of behavioral and autonomic responses following administration of 5-HT-enhancing drugs and direct 5-HT agonists administered alone or in combination, and we briefly discuss the receptor mediation of these responses. Considering species differences, we identify a distinct set of behavioral and autonomic responses that are consistently observed following administration of direct and indirect 5-HT agonists. Finally, we discuss the importance of a standardized assessment of SS responses in rodents and the utility of animal models of the SS in translational studies, and provide suggestions for future research.

Key Findings

Finally, we discuss the importance of a standardized assessment of SS responses in rodents and the utility of animal models of the SS in translational studies, and provide suggestions for future research.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Mice
  • Rats
  • Serotonin Agents
  • Serotonin Syndrome

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: 5-htp

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09