Thiamine supplementation for the treatment of heart failure: a review of the literature

source extracted confidence: high 2026-04-09
#heart-failure #humans #thiamine #thiamine-deficiency #ventricular-function-left

Thiamine supplementation for the treatment of heart failure: a review of the literature

DiNicolantonio et al., 2013 | Congest Heart Fail | Systematic Review

Citation

DiNicolantonio James J, Niazi Asfandyar K, ... Ventura Hector O. Thiamine supplementation for the treatment of heart failure: a review of the literature. Congest Heart Fail. 2013;19(4):214-22. doi:10.1111/chf.12037

Abstract

A systematic review of the literature was performed by searching Pubmed and EMBASE databases using the terms "thiamine," "vitamin B1," "heart failure," "systolic dysfunction," "ventricular dysfunction," "cardiomyopathy," "ventricular failure," and "systolic failure." Relevant trials and articles were evaluated pertaining to thiamine deficiency in patients with heart failure (HF) and references were searched for further inclusion of articles. A total of 20 articles were reviewed and summarized in detail. While more research is needed to fully elucidate the clinical thiamine deficiency in HF patients, recent evidence has indicated that supplementing with thiamine in HF patients has the potential to improve left ventricular ejection fraction. Thiamine deficiency appears to be not uncommon in patients with HF, and supplementation with thiamine has been shown to improve cardiac function, urine output, weight loss, and signs and symptoms of HF. Therefore, this simple therapy should be tested in large-scale randomized clinical trial to further determine the effects of thiamine in HF patients.

Key Findings

Therefore, this simple therapy should be tested in large-scale randomized clinical trial to further determine the effects of thiamine in HF patients.

Outcomes Measured

  • systolic blood pressure

Population

Field Value
Population heart failure
Sample Size See abstract
Age Range See abstract
Condition deficiency

MeSH Terms

  • Heart Failure
  • Humans
  • Thiamine
  • Thiamine Deficiency
  • Ventricular Function, Left
  • Vitamin B Complex

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: thiamine-heart

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09