Topical nicotinamide for seborrheic dermatitis: an open randomized study

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Topical nicotinamide for seborrheic dermatitis: an open randomized study

Fabbrocini et al., 2014 | J Dermatolog Treat | Rct

Citation

Fabbrocini Gabriella, Cantelli Mariateresa, Monfrecola Giuseppe. Topical nicotinamide for seborrheic dermatitis: an open randomized study. J Dermatolog Treat. 2014-Jun;25(3):241-5. doi:10.3109/09546634.2013.814754

Abstract

BACKGROUND: Treatment of seborrheic dermatitis (SD) includes various options with different success and safety limitations. OBJECTIVE: To evaluate the efficacy of topical nicotinamide (NCT) in the treatment of SD. METHODS: A total of 48 patients with mild to moderate SD of the face were enrolled in the study (36 males and 12 females; age 20-50 years). Patients were randomized into two groups A and B, who were treated once a day with topical administration of NCT 4% cream and with the vehicle without NCT (placebo), respectively. Clinical measures were assessed by erythema, scaling, and infiltration, which were evaluated using a four-point scale 0-3 before starting treatment and after 2, 6, and 12 weeks' therapy. RESULTS: In comparison with baseline, a reduction of 75% of the total score was observed in patients treated with NCT, whereas for placebo-treated patients the reduction was of 35% (p < 0.05). CONCLUSION: Topical NCT 4% can have a potential for the treatment of SD.

Key Findings

In comparison with baseline, a reduction of 75% of the total score was observed in patients treated with NCT, whereas for placebo-treated patients the reduction was of 35% (p < 0.05).

Outcomes Measured

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Population

Field Value
Population mild to moderate sd
Sample Size 48
Age Range age 20-50
Condition See abstract

MeSH Terms

  • Administration, Topical
  • Adult
  • Dermatitis, Seborrheic
  • Dermatologic Agents
  • Face
  • Female
  • Humans
  • Male
  • Middle Aged
  • Niacinamide
  • Skin Cream
  • Young Adult

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: niacin-skin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09