Iron chelators for acute stroke

source extracted confidence: high 2026-04-09
#humans #iron-chelating-agents #neuroprotective-agents #stroke

Iron chelators for acute stroke

Ma et al., 2012 | Cochrane Database Syst Rev | Systematic Review

Citation

Ma Junpeng, You Chao, Hao Li. Iron chelators for acute stroke. Cochrane Database Syst Rev. 2012-Sep-12(9):CD009280. doi:10.1002/14651858.CD009280.pub2

Abstract

BACKGROUND: Stroke is a serious public health problem that causes morbidity and mortality throughout the world. Iron chelators are potential neuroprotective drugs to treat patients with both hemorrhagic and ischemic stroke. OBJECTIVES: To evaluate the effectiveness and safety of the administration of iron chelators in patients with acute stroke. SEARCH METHODS: We searched the Cochrane Stroke Group Trials Register (May 2012), the Chinese Stroke Trials Register (May 2012), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2012, Issue 1), MEDLINE (1950 to May 2012), EMBASE (1980 to May 2012), Science Citation Index (1980 to May 2012) and three Chinese databases. In an effort to identify further published, unpublished and ongoing trials we searched ongoing trials registers, checked reference lists, and contacted authors and pharmaceutical companies. SELECTION CRITERIA: We included published and unpublished randomized controlled trials (RCTs) of iron chelator versus no iron chelator or placebo for the treatment of acute stroke. DATA COLLECTION AND ANALYSIS: Two review authors independently screened search results to identify the full texts of potentially relevant studies for inclusion. From the results of the screened searches two review authors independently selected trials meeting the inclusion criteria, with no disagreement. MAIN RESULTS: We found no completed RCTs eligible for inclusion in the review. We identified one ongoing RCT but no data were available. AUTHORS' CONCLUSIONS: There is insufficient evidence to support or refute the use of iron chelators for the treatment of acute stroke. Further RCTs are required to assess the effect of iron chelators in people with acute stroke.

Key Findings

We found no completed RCTs eligible for inclusion in the review. We identified one ongoing RCT but no data were available. AUTHORS' CONCLUSIONS: There is insufficient evidence to support or refute the use of iron chelators for the treatment of acute stroke. Further RCTs are required to assess the effect of iron chelators in people with acute stroke.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population both hemorrhagic and ischemic
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Iron Chelating Agents
  • Neuroprotective Agents
  • Stroke

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: iron

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09