Feverfew for migraine prophylaxis: a systematic review

Saranitzky et al., 2009 | J Diet Suppl | Systematic Review

Citation

Saranitzky Elisa, White C Michael, ... Coleman Craig I. Feverfew for migraine prophylaxis: a systematic review. J Diet Suppl. 2009;6(2):91-103. doi:10.1080/19390210902861809

Abstract

Feverfew has been studied for the treatment of migrane in several studies and the pharmacologic mechanisms are preliminarily understood. We performed a systematic review of randomized controlled trials and present the clinical findings and potential implications. The modality of data collection and reporting in the individual studies does not support a pooling of results, but does suggest benefit of feverfew in migraine prophylaxis for at least subsets of the population with the disorder. Pharmacologically, there is some potential for concern with long-term dosing given its cyclooxygenase-2 inhibiting effects and longer-term studies will be needed to ameliorate these concerns in coronary disease patients.

Key Findings

Pharmacologically, there is some potential for concern with long-term dosing given its cyclooxygenase-2 inhibiting effects and longer-term studies will be needed to ameliorate these concerns in coronary disease patients.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Cyclooxygenase 2 Inhibitors
Humans
Migraine Disorders
Phytotherapy
Plant Extracts
Tanacetum parthenium

Evidence Classification

Level: Systematic Review
Publication Types: Journal Article, Systematic Review
Vertical: feverfew

Provenance

PMID: 22435410
DOI: 10.1080/19390210902861809
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09