Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine

Huang et al., 2011 | Mini Rev Med Chem | Systematic Review

Citation

Huang Z-J, Zeng Y, ... Chen W-M. Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine. Mini Rev Med Chem. 2011-Nov;11(13):1122-9

Abstract

Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

Key Findings

The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

Outcomes Measured

inflammatory markers

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Alzheimer Disease
Animals
Anti-Infective Agents
Anti-Inflammatory Agents
Antimalarials
Antineoplastic Agents
Bacterial Infections
Berberine
Coptis chinensis
Diabetes Mellitus
Drug Discovery
Drugs, Chinese Herbal
Humans
Hypoglycemic Agents
Malaria
Medicine, Chinese Traditional
Mycoses
Neoplasms

Evidence Classification

Level: Systematic Review
Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
Vertical: berberine

Provenance

PMID: 22353221
DOI: (not available)
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09