Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production

source extracted confidence: high 2026-04-09
#apitherapy #cell-survival #cells-cultured #chromatography-high-pressure-liquid #collagen-type-i

Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production

Park et al., 2011 | J Med Food | Other

Citation

Park Hye Min, Hwang Eunson, ... Kim Sun Yeou. Royal jelly protects against ultraviolet B-induced photoaging in human skin fibroblasts via enhancing collagen production. J Med Food. 2011-Sep;14(9):899-906. doi:10.1089/jmf.2010.1363

Abstract

Royal jelly (RJ) is a honeybee product containing proteins, carbohydrates, fats, free amino acids, vitamins, and minerals. As its principal unsaturated fatty acid, RJ contains 10-hydroxy-2-decenoic acid (10-HDA), which may have antitumor and antibacterial activity and a capacity to stimulate collagen production. RJ has attracted interest in various parts of the world for its pharmacological properties. However, the effects of RJ on ultraviolet (UV)-induced photoaging of the skin have not been reported. In this study we measured the 10-HDA content of RJ by high-performance liquid chromatography and tested the effects of RJ on UVB-induced skin photoaging in normal human dermal fibroblasts. The effects of RJ and 10-HDA on UVB-induced photoaging were tested by measuring procollagen type I, transforming growth factor (TGF)-β1, and matrix metalloproteinase (MMP)-1 after UVB irradiation. The RJ contained about 0.211% 10-HDA. The UVB-irradiated human skin fibroblasts treated with RJ and 10-HDA had increased procollagen type I and TGF-β1 productions, but the level of MMP-1 was not changed. Thus RJ may potentially protect the skin from UVB-induced photoaging by enhancing collagen production.

Key Findings

Thus RJ may potentially protect the skin from UVB-induced photoaging by enhancing collagen production.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Apitherapy
  • Cell Survival
  • Cells, Cultured
  • Chromatography, High Pressure Liquid
  • Collagen Type I
  • Enzyme-Linked Immunosorbent Assay
  • Fatty Acids
  • Fatty Acids, Monounsaturated
  • Humans
  • Matrix Metalloproteinase 1
  • Osmolar Concentration
  • Procollagen
  • Republic of Korea
  • Skin
  • Skin Aging
  • Sunscreening Agents
  • Transforming Growth Factor beta1
  • Ultraviolet Rays
  • Up-Regulation
  • Royal Jelly

Evidence Classification

  • Level: Other
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't
  • Vertical: royal-jelly

Provenance

Source extracted via PubMed E-utilities API on 2026-04-12