Genome-wide association study identifies common variants associated with circulating vitamin E levels

source extracted confidence: high 2026-04-09
#adult #aged #cohort-studies #female #genetic-variation

Genome-wide association study identifies common variants associated with circulating vitamin E levels

Major et al., 2011 | Hum Mol Genet | Meta Analysis

Citation

Major Jacqueline M, Yu Kai, ... Albanes Demetrius. Genome-wide association study identifies common variants associated with circulating vitamin E levels. Hum Mol Genet. 2011-Oct-01;20(19):3876-83. doi:10.1093/hmg/ddr296

Abstract

In genome-wide association studies (GWAS) of common genetic variants associated with circulating alpha- and gamma-tocopherol concentrations in two adult cohorts comprising 5006 men of European descent, we observed three loci associated with alpha-tocopherol levels, two novel single-nucleotide polymorphisms (SNPs), rs2108622 on 19pter-p13.11 (P= 1.7 × 10(-8)) and rs11057830 on 12q24.31 (P= 2.0 × 10(-8)) and confirmed a previously reported locus marked by rs964184 on 11q23.3 (P= 2.7 × 10(-10)). The three SNPs have been reported to be associated with lipid metabolism and/or regulation. We replicated these findings in a combined meta-analysis with two independent samples, P= 7.8 × 10(-12) (rs964184 on 11q23.3 near BUD13, ZNF259 and APOA1/C3/A4/A5), P= 1.4 × 10(-10) (rs2108622 on 19pter-p13.11 near CYP4F2) and P= 8.2 × 10(-9) (rs11057830 on 12q24.31 near SCARB1). Combined, these SNPs explain 1.7% of the residual variance in log alpha-tocopherol levels. In one of the two male GWAS cohorts (n= 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P< 1 × 10(-4) identified.

Key Findings

In one of the two male GWAS cohorts (n= 992), no SNPs were significantly associated with gamma-tocopherol concentrations after including data from the replication sample for 71 independent SNPs with P< 1 × 10(-4) identified.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 992
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Aged
  • Cohort Studies
  • Female
  • Genetic Variation
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Neoplasms
  • Polymorphism, Single Nucleotide
  • Vitamin E
  • White People

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09