Sleep disorders in children

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#5-hydroxytryptophan #child #humans #learning-disabilities #melatonin

Sleep disorders in children

Bruni et al., 2010 | BMJ Clin Evid | Systematic Review

Citation

Bruni Oliveiero, Novelli Luana. Sleep disorders in children. BMJ Clin Evid. 2010-Sep-27;2010

Abstract

INTRODUCTION: Sleep disorders may affect between 20% and 30% of young children, and include problems getting to sleep (dyssomnias), or undesirable phenomena during sleep (parasomnias), such as sleep terrors and sleepwalking. Children with physical or learning disabilities are at increased risk of sleep disorders. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for dyssomnias in children? What are the effects of treatments for parasomnias in children? We searched: Medline, Embase, The Cochrane Library, and other important databases up to September 2009 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 28 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: antihistamines; behavioural therapy plus antihistamines, plus benzodiazepines, or plus chloral and derivatives; benzodiazepines alone; exercise; extinction and graduated extinction; 5-hydroxytryptophan; light therapy; melatonin; safety/protective interventions for parasomnias; scheduled waking (for parasomnias); sleep hygiene; and sleep restriction.

Key Findings

We found 28 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population young children
Sample Size See abstract
Age Range See abstract
Condition sleep

MeSH Terms

  • 5-Hydroxytryptophan
  • Child
  • Humans
  • Learning Disabilities
  • Melatonin
  • Parasomnias
  • Sleep
  • Sleep Wake Disorders

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: 5-htp

Provenance

  • PMID: 21418676
  • DOI: (not available)
  • PMCID: PMC3217667
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09