Dentin hypersensitivity and oxalates: a systematic review

source extracted confidence: high 2026-04-09
#bias #controlled-clinical-trials-as-topic #dentin-desensitizing-agents #dentin-sensitivity #humans

Dentin hypersensitivity and oxalates: a systematic review

Cunha-Cruz et al., 2011 | J Dent Res | Meta Analysis

Citation

Cunha-Cruz J, Stout J R, ... Wataha J C. Dentin hypersensitivity and oxalates: a systematic review. J Dent Res. 2011-Mar;90(3):304-10. doi:10.1177/0022034510389179

Abstract

Treatment of dentin hypersensitivity with oxalates is common, but oxalate efficacy remains unclear. Our objective was to systematically review clinical trials reporting an oxalate treatment compared with no treatment or placebo with a dentin hypersensitivity outcome. Risk-of-bias assessment and data extraction were performed independently by two reviewers. Standardized mean differences (SMD) were estimated by random-effects meta-analysis. Of 677 unique citations, 12 studies with high risk-of-bias were included. The summary SMD for 3% monohydrogen-monopotassium oxalate (n = 8 studies) was -0.71 [95% Confidence Interval: -1.48, 0.06]. Other treatments, including 30% dipotassium oxalate (n = 1), 30% dipotassium oxalate plus 3% monohydrogen monopotassium oxalate (n = 3), 6% monohydrogen monopotassium oxalate (n = 1), 6.8% ferric oxalate (n = 1), and oxalate-containing resin (n = 1), also were not statistically significantly different from placebo treatments. With the possible exception of 3% monohydrogen monopotassium oxalate, available evidence currently does not support the recommendation of dentin hypersensitivity treatment with oxalates.

Key Findings

With the possible exception of 3% monohydrogen monopotassium oxalate, available evidence currently does not support the recommendation of dentin hypersensitivity treatment with oxalates.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 8
Age Range See abstract
Condition See abstract

MeSH Terms

  • Bias
  • Controlled Clinical Trials as Topic
  • Dentin Desensitizing Agents
  • Dentin Sensitivity
  • Humans
  • Oxalates
  • Pain Measurement

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Systematic Review
  • Vertical: iron

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09