Folate intake and the risk of colorectal cancer: a systematic review and meta-analysis

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#clinical-trials-as-topic #colorectal-neoplasms #dietary-supplements #folic-acid #humans

Folate intake and the risk of colorectal cancer: a systematic review and meta-analysis

Kennedy et al., 2011 | Cancer Epidemiol | Meta Analysis

Citation

Kennedy Deborah A, Stern Seth J, ... Koren Gideon. Folate intake and the risk of colorectal cancer: a systematic review and meta-analysis. Cancer Epidemiol. 2011-Feb;35(1):2-10. doi:10.1016/j.canep.2010.11.004

Abstract

INTRODUCTION: Folic acid fortification and supplementation to prevent neural tube defects has led to concerns regarding increased risk of colorectal cancer. The results of existing studies have been inconclusive. The purpose was to examine the relationship between level of folate intake and the incidence of colorectal cancer. METHODS: A systematic review and meta analysis were conducted. MEDLINE, Embase, and SCOPUS were searched from inception to October 2009 with the following search terms "folic acid," "folate", "colorectal cancer," "colon neoplasms," rectal neoplasms." Observational studies in adult populations were included that defined levels of folate intake and incidence of colorectal cancer. RESULT: Out of 6427 references, 27 studies met our inclusion criteria. The summary risk estimate for case control studies comparing high versus low total folate intake was 0.85 (CI 95% 0.74-0.99) with no significant heterogeneity among studies. Similarly, for cohort studies, the resulting summary risk estimate for high versus low dietary folate intake was 0.92 (CI 95% 0.81-1.05) with no significant heterogeneity. However, defining what represents a higher intake of folic acid is difficult as there is variability in the upper limit of folic acid intake used in the studies. DISCUSSION: These results suggest that higher folate intake levels offer a reduction in one of the perceived risks associated with developing colorectal cancer. These data can serve to help reassure women planning a pregnancy to increase folic intake during the preconception period to levels sufficient to prevent neural tube defects.

Key Findings

These data can serve to help reassure women planning a pregnancy to increase folic intake during the preconception period to levels sufficient to prevent neural tube defects.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population adult populations
Sample Size 27
Age Range See abstract
Condition See abstract

MeSH Terms

  • Clinical Trials as Topic
  • Colorectal Neoplasms
  • Dietary Supplements
  • Folic Acid
  • Humans
  • Incidence
  • Risk Factors
  • Vitamin B Complex

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: folate-cancer

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09