Genome-wide meta-analyses identify multiple loci associated with smoking behavior

source extracted confidence: high 2026-04-09
#age-factors #alleles #chromosome-mapping #female #genome

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Unknown et al., 2010 | Nat Genet | Meta Analysis

Citation

. Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet. 2010-May;42(5):441-7. doi:10.1038/ng.571

Abstract

Consistent but indirect evidence has implicated genetic factors in smoking behavior. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,000). We identified three loci associated with number of cigarettes smoked per day. The strongest association was a synonymous 15q25 SNP in the nicotinic receptor gene CHRNA3 (rs1051730[A], beta = 1.03, standard error (s.e.) = 0.053, P = 2.8 x 10(-73)). Two 10q25 SNPs (rs1329650[G], beta = 0.367, s.e. = 0.059, P = 5.7 x 10(-10); and rs1028936[A], beta = 0.446, s.e. = 0.074, P = 1.3 x 10(-9)) and one 9q13 SNP in EGLN2 (rs3733829[G], beta = 0.333, s.e. = 0.058, P = 1.0 x 10(-8)) also exceeded genome-wide significance for cigarettes per day. For smoking initiation, eight SNPs exceeded genome-wide significance, with the strongest association at a nonsynonymous SNP in BDNF on chromosome 11 (rs6265[C], odds ratio (OR) = 1.06, 95% confidence interval (Cl) 1.04-1.08, P = 1.8 x 10(-8)). One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.

Key Findings

One SNP located near DBH on chromosome 9 (rs3025343[G], OR = 1.12, 95% Cl 1.08-1.18, P = 3.6 x 10(-8)) was significantly associated with smoking cessation.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 74053
Age Range See abstract
Condition See abstract

MeSH Terms

  • Age Factors
  • Alleles
  • Chromosome Mapping
  • Female
  • Genome
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Male
  • Molecular Epidemiology
  • Odds Ratio
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Receptors, Nicotinic
  • Smoking

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
  • Vertical: niacin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09