The antidiabetic effect of onion and garlic in experimental diabetic rats: meta-analysis

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#allyl-compounds #animals #blood-glucose #body-weight #cysteine

The antidiabetic effect of onion and garlic in experimental diabetic rats: meta-analysis

Kook et al., 2009 | J Med Food | Meta Analysis

Citation

Kook Sejeong, Kim Gun-Hee, Choi Kiheon. The antidiabetic effect of onion and garlic in experimental diabetic rats: meta-analysis. J Med Food. 2009-Jun;12(3):552-60. doi:10.1089/jmf.2008.1071

Abstract

This study was carried out to evaluate the effect of onion and garlic in experimentally induced diabetic rats by meta-analysis of related studies. Ten systematic literature searches were conducted on the National Center for Biotechnology Information database, the DBpia database, and the Koreanstudies Information Service System database. Most studies had three groups-the normal group, the treated diabetic group, and the untreated diabetic group-the means of which were compared for various effect factors between two of the groups. The effect factors were blood glucose concentration, body weight, and the concentrations of plasma total cholesterol, plasma triglycerides, plasma high-density lipoprotein-cholesterol, and liver glycogen. The treated diabetic group included diabetic rats supplemented with either onion or garlic extract or with single components, including S-allylcysteine sulfoxide, S-methylcysteine sulfoxide, and diallyl trisulfide. The effects of each factor were investigated by the standardized mean difference between the treated diabetic group and the diabetic group. Because homogeneity among studies for some effect factors is not plausible, the random effect estimates were calculated. In the meta-analysis, the antidiabetic effects of onion extract and single components were significant for glucose concentration and body weight (P < .05), but the effects of garlic extract were not significant. The results of the meta-analysis suggested that the single component intake and onion extract intake may be effective for lowering plasma glucose concentrations and body weight.

Key Findings

The results of the meta-analysis suggested that the single component intake and onion extract intake may be effective for lowering plasma glucose concentrations and body weight.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Allyl Compounds
  • Animals
  • Blood Glucose
  • Body Weight
  • Cysteine
  • Diabetes Mellitus, Experimental
  • Garlic
  • Hypoglycemic Agents
  • Onions
  • Phytotherapy
  • Plant Extracts
  • Rats
  • Sulfides

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't
  • Vertical: garlic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09