Management of tinnitus: oral treatment with melatonin and sulodexide

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#administration-oral #adult #aged #drug-therapy-combination #female

Management of tinnitus: oral treatment with melatonin and sulodexide

Neri et al., 2009 | J Biol Regul Homeost Agents | Rct

Citation

Neri G, Baffa C, ... Croce A. Management of tinnitus: oral treatment with melatonin and sulodexide. J Biol Regul Homeost Agents. 2009;23(2):103-10

Abstract

The main problem arising from tinnitus is the disturbance it causes in day-to-day life and disturbance in sleep leading to fatigue and general discomfort. We attempted to study the effect of melatonin in conjunction with Sulodexide as a treatment method for tinnitus and evaluate its effectiveness. We studied 102 patients suffering from tinnitus with a Prospective Randomised Controlled Study conducted in a tertiary care ENT department. After randomisation, 34 patients were treated with melatonin and Sulodexide, another 34 were treated with melatonin alone, and the remaining 34 (control group) were managed without therapy in order to evaluate spontaneous variations in quality of tinnitus. Patients were assessed prospectively with Tinnitus Handicap Inventory and Acufenometry both pre-treatment and post-treatment. Among the patients we studied, we found better results with both Tinnitus Handicap Inventory and Acufenometry in the group who received melatonin and Sulodexide as against melatonin alone. Any improvement was noted in the control group. In conclusion, our opinion is that melatonin in combination with Sulodexide is a viable treatment option for patients suffering from central or sensorineural tinnitus.

Key Findings

In conclusion, our opinion is that melatonin in combination with Sulodexide is a viable treatment option for patients suffering from central or sensorineural tinnitus.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 102
Age Range See abstract
Condition sleep

MeSH Terms

  • Administration, Oral
  • Adult
  • Aged
  • Drug Therapy, Combination
  • Female
  • Glycosaminoglycans
  • Humans
  • Male
  • Melatonin
  • Middle Aged
  • Prospective Studies
  • Quality of Life
  • Tinnitus

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: melatonin-tinnitus

Provenance

  • PMID: 19589291
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09