Current opinion on the science of organophosphate pesticides and toxic stress: a systematic review

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#animals #humans #organophosphorus-compounds #pesticides #stress-physiological

Current opinion on the science of organophosphate pesticides and toxic stress: a systematic review

Soltaninejad et al., 2009 | Med Sci Monit | Meta Analysis

Citation

Soltaninejad Kambiz, Abdollahi Mohammad. Current opinion on the science of organophosphate pesticides and toxic stress: a systematic review. Med Sci Monit. 2009-Mar;15(3):RA75-90

Abstract

The aim of this article is to provide a brief review of the current status of our knowledge related to organophosphates (OPs) and oxidative stress. For this purpose, we performed a systematic review on the literatures using Pubmed and Scopus databases without date limitation. A total of 127 articles including 112 experimental and 15 human studies were found relevant and reviewed. Data were categorized according to experimental and clinical studies. Occurrence of cell membrane lipid peroxidation, alteration in the levels of total antioxidant capacity, total thiol molecules, and protective effects of natural and synthetic antioxidants against OP-induced histopathological and biochemical alterations are the most important evidences for involvement of oxidative stress in OP-induced toxicity. It is concluded that evaluation of blood oxidative stress parameters can be useful for monitoring exposed people. Supplementing of people in exposure to OPs with potent antioxidants such as vitamin E and C is recommended. Much human studies with higher sample size and better exclusion of biasing factors are still needed.

Key Findings

Much human studies with higher sample size and better exclusion of biasing factors are still needed.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Humans
  • Organophosphorus Compounds
  • Pesticides
  • Stress, Physiological

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: vitamin-e

Provenance

  • PMID: 19247260
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09