Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome

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#adolescent #adult #calcium #double-blind-method #dydrogesterone

Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome

Khajehei et al., 2009 | Int J Gynaecol Obstet | Rct

Citation

Khajehei Marjan, Abdali Khadijeh, ... Tabatabaee Hamid Reza. Effect of treatment with dydrogesterone or calcium plus vitamin D on the severity of premenstrual syndrome. Int J Gynaecol Obstet. 2009-May;105(2):158-61. doi:10.1016/j.ijgo.2009.01.016

Abstract

OBJECTIVE: To compare the effects of dydrogesterone and calcium plus vitamin D in women with severe premenstrual syndrome (PMS). METHOD: In this randomized, double-blind, placebo-controlled study, 180 Shiraz University students with PMS used questionnaires daily to rate their symptoms for 2 menstrual cycles. Then, the students were randomly assigned to take a tablet containing either 5 mg of dydrogesterone, 500 mg of calcium plus 200 mg of vitamin D, or a placebo twice daily from the 15th to the 24th day of the cycle for 2 more cycles, and to use the same questionnaires during the intervention cycles. The collected data were then analyzed by repeated-measurement design and multilevel modeling tests. RESULT: Treatment with dydrogesterone or calcium plus vitamin D decreased symptom severity in a similar way (by 4.64% and 4.20%, respectively) and placebo was associated with a 3.42% decrease. CONCLUSION: Treatment with dydrogesterone or calcium plus vitamin D had a similar effect on symptom severity in women with PMS.

Key Findings

Treatment with dydrogesterone or calcium plus vitamin D had a similar effect on symptom severity in women with PMS.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adolescent
  • Adult
  • Calcium
  • Double-Blind Method
  • Dydrogesterone
  • Female
  • Humans
  • Premenstrual Syndrome
  • Progestins
  • Prospective Studies
  • Vitamin D
  • Young Adult

Evidence Classification

  • Level: Rct
  • Publication Types: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
  • Vertical: calcium-pms

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09