Effects of nattokinase on blood pressure: a randomized, controlled trial

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#adult #aged #aged-80-and-over #blood-pressure #dietary-supplements

Effects of nattokinase on blood pressure: a randomized, controlled trial

Kim et al., 2008 | Hypertens Res | Rct

Citation

Kim Ji Young, Gum Si Nae, ... Lee Jong Ho. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008-Aug;31(8):1583-8. doi:10.1291/hypres.31.1583

Abstract

The objective of this study was to examine the effects of nattokinase supplementation on blood pressure in subjects with pre-hypertension or stage 1 hypertension. In a randomized, double-blind, placebo-controlled trial, 86 participants ranging from 20 to 80 years of age with an initial untreated systolic blood pressure (SBP) of 130 to 159 mmHg received nattokinase (2,000 FU/capsule) or a placebo capsule for 8 weeks. Seventy-three subjects completed the protocol. Compared with the control group, the net changes in SBP and diastolic blood pressure (DBP) were -5.55 mmHg (95% confidence interval [CI], -10.5 to -0.57 mmHg; p<0.05) and -2.84 mmHg (CI, -5.33 to -0.33 mmHg; p<0.05), respectively, after the 8-week intervention. The corresponding net change in renin activity was -1.17 ng/mL/h for the nattokinase group compared with the control group (p<0.05). In conclusion, nattokinase supplementation resulted in a reduction in SBP and DBP. These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.

Key Findings

These findings suggest that increased intake of nattokinase may play an important role in preventing and treating hypertension.

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population pre
Sample Size 86
Age Range 20 to 80 years
Condition hypertension

MeSH Terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Pressure
  • Dietary Supplements
  • Female
  • Humans
  • Hypertension
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A
  • Placebos
  • Renin
  • Soy Foods
  • Subtilisins
  • Treatment Outcome

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
  • Vertical: nattokinase

Provenance

Source extracted via PubMed E-utilities API on 2026-04-12