Magnesium sulfate in emergency department patients with hypertension

source extracted confidence: high 2026-04-09
#aged #blood-pressure #calcium-channel-blockers #emergency-medical-services #female

Magnesium sulfate in emergency department patients with hypertension

Bayir et al., 2009 | Biol Trace Elem Res | Rct

Citation

Bayir Ayşegül, Kara Hasan, ... Kara Fatih. Magnesium sulfate in emergency department patients with hypertension. Biol Trace Elem Res. 2009-Apr;128(1):38-44. doi:10.1007/s12011-008-8256-y

Abstract

To compare the effect of IV magnesium with other antihypertensives in emergency department (ED) patients with hypertension. ED patients with a systolic BP > 135 mmHg or diastolic BP > 85 were approached for entry into the study. Those granting consent were randomly placed into one of three treatment groups: (1) 1.5 gm IV MgSO(4) (n = 42), (2) a parenteral or oral antihypertensive agent (n = 41), (3) both IV MgSO(4) and an antihypertensive agent (n = 44). Systolic and diastolic blood pressures were measured at entry into the study and at 15, 30, 45, and 60 min after magnesium or other antihypertensive medications were given. The main outcome measure was blood pressure at 60 min, and results were compared using one-way analysis of variance with the post hoc Tukey HSD test. Compared to systolic and diastolic blood pressures at time 0, both were lower at 15, 30, 45, and 60 min in all groups (p < 0.05). No significant difference in systolic or diastolic BP at any time point was observed when response to treatment was compared between the three groups. Intravenous MgSO(4) is as effective as antihypertensives at lowering BP in emergency department patients.

Key Findings

Intravenous MgSO(4) is as effective as antihypertensives at lowering BP in emergency department patients.

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population hypertension
Sample Size 42
Age Range See abstract
Condition hypertension

MeSH Terms

  • Aged
  • Blood Pressure
  • Calcium Channel Blockers
  • Emergency Medical Services
  • Female
  • Humans
  • Hypertension
  • Magnesium Sulfate
  • Male
  • Middle Aged

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: magnesium-blood-pressure

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09