Advances in drug discovery to assess cholinergic neurotransmission: a systematic review

Ferreira et al., 2008 | Curr Drug Discov Technol | Systematic Review

Citation

Ferreira Vitor F, da Rocha David R, ... Santos Wilson C. Advances in drug discovery to assess cholinergic neurotransmission: a systematic review. Curr Drug Discov Technol. 2008-Sep;5(3):236-49

Abstract

Neurotransmission is essential to physiological processes of cellular communication. The search for new molecules that may influence neurotransmission systems is an open field with possible impact on several pathophysiological conditions or diseases: Alzheimer's disease, Parkinsonism and myasthenia gravis, etc. The present review describes the most important aspects of cholinergic neurotransmission, as well as natural and synthetic compounds that, as clinical or experimental drugs, are able to influence this transmission. The pharmacological effects of substances that bind to muscarinic or nicotinic cholinergic receptors, along with their corresponding affinities will also be presented.

Key Findings

The pharmacological effects of substances that bind to muscarinic or nicotinic cholinergic receptors, along with their corresponding affinities will also be presented.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Animals
Cholinergic Agents
Drug Discovery
Humans
Receptors, Muscarinic
Receptors, Nicotinic
Synaptic Transmission

Evidence Classification

Level: Systematic Review
Publication Types: Journal Article, Systematic Review
Vertical: niacin

Provenance

PMID: 18690892
DOI: (not available)
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09