Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress

source extracted confidence: high 2026-04-09
#adult #cerebral-cortex #cognition #diet #double-blind-method

Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress

Baumeister et al., 2008 | Nutr Neurosci | Rct

Citation

Baumeister J, Barthel T, ... Weiss M. Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci. 2008-Jun;11(3):103-10. doi:10.1179/147683008X301478

Abstract

The aim of this study was to investigate the effect of phosphatidylserine (PS) on cognition and cortical activity after mental stress. After familiarization, 16 healthy subjects completed cognitive tasks after induced stress in a test-re-test design (T1 and T2). Directly after T1, subjects were assigned double-blind to either PS or placebo groups followed by T2 after 42 days. At T1 and T2, cortical activity was measured at baseline and immediately after stress with cognitive tasks using electro-encephalography (EEG). EEG was recorded at 17 electrode positions and fast Fourier transforms (FFT) determined power at Theta, Alpha-1, Alpha-2, Beta-1 and Beta-2. Statistics were calculated using ANOVA (group x trial x time). The main finding of the study was that chronic supplementation of phosphatidylserine significantly decreases Beta-1 power in right hemispheric frontal brain regions (F8; P < 0.05) before and after induced stress. The results for Beta-1 power in the PS group were connected to a more relaxed state compared to the controls.

Key Findings

The results for Beta-1 power in the PS group were connected to a more relaxed state compared to the controls.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 1
Age Range See abstract
Condition stress

MeSH Terms

  • Adult
  • Cerebral Cortex
  • Cognition
  • Diet
  • Double-Blind Method
  • Electroencephalography
  • Heart Rate
  • Humans
  • Male
  • Phosphatidylserines
  • Placebos
  • Stress, Psychological

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial
  • Vertical: phosphatidylserine-cognition

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09