Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women

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#cholesterol-hdl #cholesterol-ldl #female #flax #humans

Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women

Patade et al., 2008 | J Womens Health (Larchmt) | Rct

Citation

Patade Anagha, Devareddy Latha, ... Arjmandi Bahram H. Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. J Womens Health (Larchmt). 2008-Apr;17(3):355-66. doi:10.1089/jwh.2007.0359

Abstract

OBJECTIVE: The objective of the study was to investigate the extent to which the daily incorporation of approximately 30 g of flaxseed, a rich source of lignans, omega-3 fatty acids, and fiber, for a period of 3 months into the diet of Native American postmenopausal women positively affects their lipid profiles. METHODS: Fifty-five mild to moderately hypercholesterolemic (> or =5.1 to < or =9.8 mmol/L) Native American postmenopausal women were randomly assigned to control (A), flaxseed (B) or flaxseed + additional oat bran fiber (C) groups. Overnight fasting venous blood was collected at baseline and at the end of the treatment period to analyze lipid parameters. RESULTS: Dietary flaxseed supplementation lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) by approximately 7% and 10%, respectively. However, the levels of high-density lipoprotein (HDL) and triglyceride remained unaltered. No changes were observed in other clinical and hematological parameters. CONCLUSIONS: The results of the present study indicate that Native American postmenopausal women benefit from regular consumption of flaxseed by reducing their risk of cardiovascular disease as seen from lowered LDL-C and total cholesterol levels.

Key Findings

Dietary flaxseed supplementation lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) by approximately 7% and 10%, respectively. However, the levels of high-density lipoprotein (HDL) and triglyceride remained unaltered. No changes were observed in other clinical and hematological parameters.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cholesterol, HDL
  • Cholesterol, LDL
  • Female
  • Flax
  • Humans
  • Hypercholesterolemia
  • Indians, North American
  • Middle Aged
  • Phytotherapy
  • Postmenopause
  • Seeds
  • Treatment Outcome
  • Triglycerides

Evidence Classification

  • Level: Rct
  • Publication Types: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
  • Vertical: flaxseed

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09