Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1

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#cardiovascular-diseases #dietary-supplements #humans #neoplasms #randomized-controlled-trials-as-topic

Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1

Pham et al., 2005 | Ann Pharmacother | Meta Analysis

Citation

Pham David Q, Plakogiannis Roda. Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1. Ann Pharmacother. 2005-Nov;39(11):1870-8

Abstract

OBJECTIVE: To review clinical trials evaluating the safety and efficacy of vitamin E supplementation in cardiovascular disease and cancer prevention. DATA SOURCES: Using the MeSH search terms alpha-tocopherol, tocopherols, vitamin E, cardiovascular diseases, cancer, malignancy, and clinical trials, a literature review was conducted to identify peer-reviewed articles in MEDLINE (1966-July 2005). STUDY SELECTION AND DATA EXTRACTION: Published materials including original research, and previous meta-analyses were included. Only English-language articles and trials on vitamin E alone or in combination with other vitamins or minerals were reviewed. Emphasis was placed on prospective, randomized, double-blind, placebo-controlled clinical trials. DATA SYNTHESIS: Eight clinical studies demonstrated contradicting results regarding the benefits of vitamin E in the prevention of cardiovascular disease and cancer. There is enough evidence from large, well-designed studies to discourage the use of vitamin E in the primary prevention of cardiovascular disease. Secondary prevention requires more adequate clinical trials with selected populations to examine protective effects of vitamin E in cardiovascular disease. The findings of the studies reviewed do not provide evidence that vitamin E may reduce the risk of cancer; thus, at the present time, we do not recommend daily vitamin E intake for cancer prevention is not recommended. CONCLUSIONS: Available data do not support the supplementation of vitamin E in cardiovascular disease and cancer prevention.

Key Findings

Available data do not support the supplementation of vitamin E in cardiovascular disease and cancer prevention.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Cardiovascular Diseases
  • Dietary Supplements
  • Humans
  • Neoplasms
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Vitamin E
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: vitamin-e

Provenance

  • PMID: 16189282
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09