The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence

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#carotenoids #cell-transformation-neoplastic #cysteine #diet #female

The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence

García-Closas et al., 2005 | Int J Cancer | Systematic Review

Citation

García-Closas Reina, Castellsagué Xavier, ... González Carlos A. The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence. Int J Cancer. 2005-Nov-20;117(4):629-37

Abstract

Our objective was to provide an update on recent epidemiologic evidence about the role of diet and nutrition on the risk of human papillomavirus (HPV) persistence and cervical neoplasia, taking HPV into account. We conducted a systematic review and qualitative classification of all observational studies controlling for HPV infection published between March 1995 and November 2003 and of all randomized clinical trials published between January 1991 and November 2003. Scientific evidence was classified as convincing, probable, possible or insufficient, as used in a previous study on diet and cancer. Thirty-three studies were eligible for this review (10 clinical trials, 8 observational prospective studies and 15 case-control studies). The few studies on HPV persistence showed a possible protective effect of fruits, vegetables, vitamins C and E, beta- and alpha-carotene, lycopene, luterin/zeaxanthin and cryptoxanthin. Evidence for a protective effect of cervical neoplasia was probable for folate, retinol and vitamin E and possible for vegetables, vitamins C and B12, alpha-carotene, beta-carotene, lycopene, lutein/zeaxanthin and cryptoxanthin. Evidence for an increased risk of cervical neoplasia associated with high blood homocysteine was probable. Results did not differ between studies looking at preneoplastic and invasive lesions or between retrospective and prospective studies. The available evidence for an association between diet and nutritional status and cervical carcinogenesis taking HPV infection into account is not yet convincing. Large cohort studies are needed to adequately assess the role of foods and nutrients in cervical HPV carcinogenesis.

Key Findings

Large cohort studies are needed to adequately assess the role of foods and nutrients in cervical HPV carcinogenesis.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Carotenoids
  • Cell Transformation, Neoplastic
  • Cysteine
  • Diet
  • Female
  • Folic Acid
  • Homocysteine
  • Humans
  • Methionine
  • Nutritional Physiological Phenomena
  • Uterine Cervical Neoplasms
  • Vitamins

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: vitamin-a

Provenance

  • PMID: 15912536
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09