A meta-analysis of randomized controlled studies on the effects of extended-release niacin in women

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#adult #aged #cholesterol-hdl #cholesterol-ldl #delayed-action-preparations

A meta-analysis of randomized controlled studies on the effects of extended-release niacin in women

Goldberg et al., 2004 | Am J Cardiol | Meta Analysis

Citation

Goldberg Anne C. A meta-analysis of randomized controlled studies on the effects of extended-release niacin in women. Am J Cardiol. 2004-Jul-01;94(1):121-4

Abstract

The present meta-analysis pooled data from 5 double-blind, placebo-controlled studies in 432 patients with dyslipidemia treated with various doses of extended-release niacin. Data were analyzed for possible gender differences in response to treatment. At all doses, mean decreases in low-density lipoprotein cholesterol were greater in women than in men; differences were significant at doses of 1,000 mg (6.8% vs 0.2%, p = 0.006), 1,500 mg (11.3% vs 5.6%, p = 0.013), 2,000 mg (14.8% vs 6.9%, p = 0.010), and 3,000 mg (28.7% vs 17.7%, p = 0.006). Decreases in triglyceride levels also tended to be greater in women than in men but reached significance only at the 1,500-mg dose (28.6% vs 20.4%, p = 0.040). No similar trends or significant gender differences were noted in levels of lipoprotein(a) and high-density lipoprotein cholesterol. This meta-analysis confirms that women respond as well as men, and possibly slightly better, to treatment with extended-release niacin and that it is a safe and effective treatment option for women with dyslipidemia.

Key Findings

This meta-analysis confirms that women respond as well as men, and possibly slightly better, to treatment with extended-release niacin and that it is a safe and effective treatment option for women with dyslipidemia.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population dyslipidemia treated with various
Sample Size 432
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Aged
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Delayed-Action Preparations
  • Double-Blind Method
  • Female
  • Humans
  • Hyperlipidemias
  • Hypolipidemic Agents
  • Lipoprotein(a)
  • Male
  • Middle Aged
  • Niacin
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Triglycerides
  • Women's Health

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: niacin

Provenance

  • PMID: 15219522
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09