Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure

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#cardiac-output-low #coenzymes #exercise #humans #hypertension

Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure

Rosenfeldt et al., 2003 | Biofactors | Systematic Review

Citation

Rosenfeldt Franklin, Hilton Deborah, ... Krum Henry. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors. 2003;18(1-4):91-100

Abstract

COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time. META-ANALYSIS OF RANDOMISED TRIALS OF COENZYME Q10 IN HEART FAILURE. In nine randomised trials of CoQ10 in heart failure published up to 2003 there were non-significant trends towards increased ejection fraction and reduced mortality. There were insufficient numbers of patients for meaningful results. To make more definitive conclusions regarding the effect of CoQ10 in cardiac failure we recommend a prospective, randomised trial with 200-300 patients per study group. Further trials of CoQ10 in physical exercise and in hypertension are recommended.

Key Findings

Further trials of CoQ10 in physical exercise and in hypertension are recommended.

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population heart failure
Sample Size 35
Age Range See abstract
Condition hypertension

MeSH Terms

  • Cardiac Output, Low
  • Coenzymes
  • Exercise
  • Humans
  • Hypertension
  • MEDLINE
  • Meta-Analysis as Topic
  • Muscle, Skeletal
  • Oxygen Consumption
  • Randomized Controlled Trials as Topic
  • Ubiquinone

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: coq10-blood-pressure

Provenance

  • PMID: 14695924
  • DOI: (not available)
  • PMCID: Not in PMC
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09