Meta-analysis of efficacy of zinc acexamate in peptic ulcer

Jiménez et al., 1992 | Digestion | Meta Analysis

Citation

Jiménez E, Bosch F, ... Baños J E. Meta-analysis of efficacy of zinc acexamate in peptic ulcer. Digestion. 1992;51(1):18-26

Abstract

Zinc acexamate (ZAC) is a new drug for the treatment of peptic ulcer. The present study was performed in order to evaluate the clinical efficacy of ZAC in peptic ulcer, using a meta-analysis of all randomized clinical trials performed with this drug. Eighteen studies were reviewed, but only 13 were considered in the final analysis. The total number of patients was 757. Control groups included placebo or H2 receptor antagonist drugs. Healing rate, assessed by endoscopy, was selected as the criterion for evaluating drug efficacy. The meta-analysis was performed using a modified version of the Mantel-Haenszel method. ZAC proved to be better than placebo in the treatment of peptic ulcer (pooled odds ratio: POR = 5.55; 95% confidence interval: 95% CI = 2.20-14.04) and not different from H2 receptor antagonist drugs when compared in patients with gastric (POR = 1.14; 95% CI = 0.47-2.72), duodenal (POR = 0.97; 95% CI = 0.13-7.33) or both ulcer types (POR = 1.10; 95% CI = 0.74-1.64). The present results show that ZAC is an effective drug for the treatment of peptic ulcer.

Key Findings

The present results show that ZAC is an effective drug for the treatment of peptic ulcer.

Outcomes Measured

• Requires manual extraction

Population

MeSH Terms

• Adult
• Aminocaproates
• Aminocaproic Acid
• Anti-Ulcer Agents
• Female
• Humans
• Male
• Meta-Analysis as Topic
• Middle Aged
• Peptic Ulcer

Evidence Classification

• Level: Meta Analysis
• Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't
• Vertical: zinc-wound

Provenance

• PMID: 1386327
• DOI: (not available)
• PMCID: Not in PMC
• Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09