[Systematic review of randomised controlled trial of iodised salt for preventing iodine deficiency disorders]

Wu et al., 2002 | Zhonghua Liu Xing Bing Xue Za Zhi | Systematic Review

Citation

Wu Taixiang, Liu Guanjian, Li Ping. [Systematic review of randomised controlled trial of iodised salt for preventing iodine deficiency disorders]. Zhonghua Liu Xing Bing Xue Za Zhi. 2002-Dec;23(6):461-5

Abstract

OBJECTIVE: To assess the effect of iodised salt for preventing iodine deficiency disorders. METHOD: Cochrane systematic review. RESULTS: Four randomised controlled trials were included. Subgroup analysis performed lay on different ages, interventions and controls. Prevalence of goitre was reduced close to 5% when using distributed iodised salt and market iodised salt plus iodine oil capsule which showed more effective than using market iodised salt alone (OR = 0.10, 95% CI: 0.02 - 0.17). The latter's prevalence of goitre was 14.7%. When using market iodised salt, the iodine urea excretion level showed different results in children group in different countries. Basically, the market iodised salt for preventing iodine deficiency of pregnancy women were effective, but a part of them did not achieve to the ideal status of iodine nutrition. CONCLUSIONS: The needs to be strictly controlled quality of iodised salt and market iodised salt plus iodised oil capsule thus can effectively reduce the prevalence of iodine deficiency disorders. However there was not enough evidence to support that market iodised salt can effectively eliminate these disorders, particularly in children. More eligibility trials are needed for providing more evidences.

Key Findings

Four randomised controlled trials were included. Subgroup analysis performed lay on different ages, interventions and controls. Prevalence of goitre was reduced close to 5% when using distributed iodised salt and market iodised salt plus iodine oil capsule which showed more effective than using market iodised salt alone (OR = 0.10, 95% CI: 0.02 - 0.17). The latter's prevalence of goitre was 14.7%. When using market iodised salt, the iodine urea excretion level showed different results in childre

Outcomes Measured

• Requires manual extraction

Population

MeSH Terms

• Adult
• Child
• China
• Goiter
• Humans
• Iodine
• Randomized Controlled Trials as Topic
• Sodium Chloride, Dietary

Evidence Classification

• Level: Systematic Review
• Publication Types: English Abstract, Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
• Vertical: iodine

Provenance

• PMID: 12667361
• DOI: (not available)
• PMCID: Not in PMC
• Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09