Calcium channel blockers for potential impaired fetal growth

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#calcium-channel-blockers #female #fetal-growth-retardation #flunarizine #humans

Calcium channel blockers for potential impaired fetal growth

Gülmezoglu et al., 2000 | Cochrane Database Syst Rev | Systematic Review

Citation

Gülmezoglu A M, Hofmeyr G J. Calcium channel blockers for potential impaired fetal growth. Cochrane Database Syst Rev. 2000;1996(2):CD000049

Abstract

BACKGROUND: Calcium channel blockers may increase the blood flow to the fetus or may improve fetal-placental cellular energy generation. This could enhance fetal growth. OBJECTIVES: The objectives of this review were to assess the effects of calcium channel blockers on fetal growth and neonatal morbidity and mortality in pregnancies where impaired fetal growth is suspected. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register. Date of the last search: December 1999. SELECTION CRITERIA: Acceptably controlled trials of calcium channel blockers in women with potential impaired fetal growth. DATA COLLECTION AND ANALYSIS: Eligibility and trial quality were assessed. MAIN RESULTS: One study of 100 women (all smokers) was included. Mean birth weight was significantly higher in women receiving flunarizine compared to the control group. No other significant differences were found. REVIEWER'S CONCLUSIONS: There is not enough evidence to evaluate the use of calcium channel blockers for impaired fetal growth. The apparent beneficial effect of calcium channel blockers on birthweight warrants further investigation.

Key Findings

One study of 100 women (all smokers) was included. Mean birth weight was significantly higher in women receiving flunarizine compared to the control group. No other significant differences were found. REVIEWER'S CONCLUSIONS: There is not enough evidence to evaluate the use of calcium channel blockers for impaired fetal growth. The apparent beneficial effect of calcium channel blockers on birthweight warrants further investigation.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Calcium Channel Blockers
  • Female
  • Fetal Growth Retardation
  • Flunarizine
  • Humans
  • Pregnancy

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: calcium

Provenance

  • PMID: 10796104
  • DOI: (not available)
  • PMCID: PMC7052780
  • Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09