Genetic Alterations From Physical Therapy in Low Back Pain and Disc Degeneration
Genetic Alterations From Physical Therapy in Low Back Pain and Disc Degeneration
NCT ID: NCT07439874 Phase: NA Status: COMPLETED Enrollment: 200 Completion: 2026-01-15
Conditions
Genetic Alteration, Low Back Pain, Physiotherapy
Interventions
Interferential therapy, Interferential therapy
Summary
Background and Scientific Rationale:
This prospective randomized controlled trial examines the combined effect of physiotherapy and vitamin D supplementation on pain, disability, interleukin-6 (IL-6) expression, and vitamin D levels in individuals with chronic low back pain (CLBP). The study details the demographic and metabolic profiles of CLBP patients compared to healthy controls, addressing a previously underexplored aspect of chronic musculoskeletal pain therapy. A total of 100 patients with chronic low back pain and 100 healthy controls were enrolled. Sixty patients with chronic low back pain were randomly assigned to either receive physiotherapy alone (which included interferential therapy and exercise) or to undergo physiotherapy combined with vitamin D supplementation over six weeks. The outcomes measured included the Numeric Pain Rating Scale (NPRS), the Arabic Oswestry Disability Index (AODI), serum IL-6 expression, and serum vitamin D levels, assessed at baseline and after the intervention.
Primary Outcome
Numerical pain rating scale